The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding

Courtney Mycroft-West1, Dunhao Su2, Stefano Elli3, Scott Guimond4, Gavin Miller5, Jeremy Turnbull2, Edwin Yates2, Marco Guerrini3, David Fernig2, Marcelo Lima1 and Mark Skidmore1.


1. Molecular & Structural Biosciences, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire, ST5 5BG, United Kingdom.
2. Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, United Kingdom.
3. Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Via G. Colombo 81, 20133, Milan, Italy.
4. School of Medicine, Keele University, Newcastle-Under-Lyme, Staffordshire, ST5 5BG, United Kingdom.
5. School of Chemistry, Keele University, Newcastle-Under-Lyme, Staffordshire, ST5 5BG, United Kingdom.